O055 Flow limitation and sleepiness in individuals without sleep apnea

Abstract Introduction Moderate-Severe Obstructive Sleep Apnea (OSA, AHI>15) disturbs sleep through frequent bouts of apnea and is associated with daytime sleepiness. However, many individuals without moderate or severe OSA (i.e. AHI≤15) also report We propose that sleepiness may be a consequence substantial flow limitation, even in the absence overt reductions airflow (apnea/hypopnea). Methods 2060 participants from MESA cohort were analysed using our validated method to estimate frequency certain limitation signal. Individuals Epworth Sleepiness Scale ≥11 points considered ‘sleepy’. Logistic regression was conducted investigate association between (binary dependent variable) (continuous) moderate-to-severe AHI≤15. Models adjusted for age, sex, race, BMI self-reported duration. Results N=832 AHI≤15 included primary models: The odds ratio (OR) predicting 2.14 (CI 1.27-3.61, per 2SD increase i.e. +11% sleep) 2.08 (1.19-3.64) when AHI. No observed moderate-severe (AHI>15, OR=1.01, 0.7-1.46). Discussion In few scored respiratory events (non-OSA mild-OSA), increased by 2 SD (11% 2-fold risk Increasing limited breaths 11% increases being sleepy equivalent 1.2 hrs less sleep. Flow an independent target ameliorating OSA.